Chromosomes and Leukemia

Double minute chromosomes in acute myeloblastic leukemia.

Two patients with acute myeloblastic leukemia (AML) with double minute chromosomes (dmins) are described. One patient had dmins in approximately one-third of bone marrow cells examined at diagnosis; no other karyotypic changes were observed. The dmins disappeared when the patient achieved a complete remission. The second patient developed acute leukemia as a second cancer, having previously rec...

Chromosomes in lymphatic leukemia of C58 mice.

A larger size of chromosomes in neoplastic cells than in cells of the corresponding normal tissues has been observed in a number of instances (2, 4, 6, 8, 9, 11, 13). Among the several proposed explanations, that of Biesele, Poyner, and Painter (9) suggested that the chromosomes of malignant cells contained muhiples of the number of chromosome strands present in those of normal cells. In order ...

Chromosomes and Causation of Human Cancer and Leukemia

Three male patients with leukemia were found with banding techniques to have unusual cytogenetic pictures in the cells of their marrow, spleen or blood. Case No. 1 (78 yr old) was that of a Ph’-negative CML with a missing Y in the blood (cultured without PHA) and marrow cells. The patient is still alive and responding to therapy. Case No. 2 (54 yr old) was considered prior to admission to have ...

Homogeneously Staining Regions or Double Minute Chromosomes in Leukemia (Brief Communication)

Sequential changes in spleen cell chromosomes during Friend virus leukemia.

Infection of BALB/c mice with varying doses of Friend virus resulted in the appearance of abnormal chromosome numbers in spleen cells. Polyploid cells were found following infection with all doses of virus used. Statistically, however, polyploidy showed no correlation with virus dose, time after infection, or their combined interaction. A total of 0.9% of all infected metaphase figures examined...